Systematic analysis of the gerontome reveals links between aging and age-related diseases

In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call the ‘gerontome’. Although some individual aging-related genes have been the subject of intense scrutiny, their analysis as a whole has been limited. In particular, the genetic interaction of aging and age-related pathologies remain a subject of debate. In this work, we perform a systematic analysis of the gerontome across species, including human aging-related genes. First, by classifying aging-related genes as pro- or anti-longevity, we define distinct pathways and genes that modulate aging in different ways. Our subsequent comparison of aging-related genes with age-related disease genes reveals species-specific effects with strong overlaps between aging and age-related diseases in mice, yet surprisingly few overlaps in lower model organisms. We discover that genetic links between aging and age-related diseases are due to a small fraction of aging-related genes which also tend to have a high network connectivity. Other insights from our systematic analysis include assessing how using datasets with genes more or less studied than average may result in biases, showing that age-related disease genes have faster molecular evolution rates and predicting new aging-related drugs based on drug-gene interaction data. Overall, this is the largest systems-level analysis of the genetics of aging to date and the first to discriminate anti- and pro-longevity genes, revealing new insights on aging-related genes as a whole and their interactions with age-related diseases

Roadmap on spatiotemporal light fields

Spatiotemporal sculpturing of light pulse with ultimately sophisticated structures represents the holy grail of the human everlasting pursue of ultrafast information transmission and processing as well as ultra-intense energy concentration and extraction. It also holds the key to unlock new extraordinary fundamental physical effects. Traditionally, spatiotemporal light pulses are always treated as spatiotemporally separable wave packet as solution of the Maxwell's equations. In the past decade, however, more generalized forms of spatiotemporally nonseparable solution started to emerge with growing importance for their striking physical effects. This roadmap intends to highlight the recent advances in the creation and control of increasingly complex spatiotemporally sculptured pulses, from spatiotemporally separable to complex nonseparable states, with diverse geometric and topological structures, presenting a bird's eye viewpoint on the zoology of spatiotemporal light fields and the outlook of future trends and open challenges.Comment: This is the version of the article before peer review or editing, as submitted by an author to Journal of Optics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i

Generalized spiral transformation for high-resolution sorting of vortex modes

We propose a generalized spiral transformation scheme that is versatile to incorporate various types of spirals such as the Archimedean spiral and the Fermat spiral. Taking advantage of the equidistant feature, we choose the Archimedean spiral mapping and demonstrate its application in high-resolution orbital angular momentum mode sorting. Given a fixed minimum spiral width, the Archimedean spiral mapping shows superior performance over the logarithmic spiral mapping. This generalized transformation scheme may also find various applications in optical transformation and can be easily extended to other fields related to conformal mapping

Compact and high-resolution optical orbital angular momentum sorter

A compact and high-resolution optical orbital angular momentum (OAM) sorter is proposed and demonstrated. The sorter comprises a quadratic fan-out mapper and a dual-phase corrector positioned in the pupil plane and the Fourier plane, respectively. The optical system is greatly simplified compared to previous demonstrations of OAM sorting, and the performance in resolution and efficiency is maintained. A folded configuration is set up using a single reflective spatial light modulator (SLM) to demonstrate the validity of the scheme. The two phase elements are implemented on the left and right halves of the SLM and connected by a right-angle prism. Experimental results demonstrate the high resolution of the compact OAM sorter, and the current limit in efficiency can be overcome by replacing with transmissive SLMs and removing the beam splitters. This novel scheme paves the way for the miniaturization and integration of high-resolution OAM sorters

Artemis

Publisher Copyright: IEEEToday, Internet service deployment is typically implemented with server replication at multiple locations. Domain name system (DNS), which translates human-readable domain names into network-routable IP addresses, is typically used for distributing users to different server replicas. However, DNS relies on several network-based queries and the queries delay the connection setup process between the client and the server replica. In this article, we propose Artemis, a practical low-latency naming and routing system that supports optimal server (replica) selection based on user-defined policies and provides lower query latencies than DNS. Artemis uses a DNS-like domain name-IP mapping for replica selection and achieves low query latency by combining the name resolution process with the transport layer handshake process. In Artemis, all server replicas at different locations share the same anycast IP address, called Service Address. Clients use the Service Address to establish a transport layer connection with the server. The client's initial handshake packet is routed over an overlay network to reach the optimal server. Then the server migrates the transport layer connection to its original unicast IP address after finishing the handshake process. After that, service discovery is completed, and the client communicates with the server directly via IP addresses. To validate the effectiveness of Artemis, we evaluate its performance via both real trace-driven simulation and real-world deployment. The result shows that Artemis can handle a large number of connections and reduce the connection setup latency compared with state-of-the-art solutions. More specifically, our deployment across 11 Google data centers shows that Artemis reduces the connection setup latency by 39.4% compared with DNS.Peer reviewe

An Itaconic Acid‐Based Phosphorus‐Containing Oligomer Endowing Epoxy Resins with Good Flame Retardancy and Toughness

Abstract With the aim to reduce the influence of flammability and brittleness of epoxy resin (EP) on its applications, a phosphorus‐containing oligomer (BID) containing phosphophenanthrene group and flexible chain segment is designed and applied to methyltetrahydrophthalic anhydride (MeTHPA) curing EP systems. Compared with EP/MeTHPA, the glass transition temperature (Tg) declines after introducing BID. But the addition of BID endows EP/MeTHPA with good flame retardancy. When the dosage is only 19.2 wt.%, the limiting oxygen index (LOI) of EP/BID/MeTHPA increases by 77% to 36% (P content: 1.5 wt.%) compared with EP and reaches the vertical combustion (UL‐94) V‐0 rating. Cone calorimetry (CC) results reveal that PHRR and THR drop by 40% and 31%. The pyrolytic process and char residue data analysis show that BID plays flame‐retardant role in gas phase and condensed phase. In addition, impact and flexural and tensile strength improve by 84%, 19% and 54% individually, proving that BID holds a potential on enhancing mechanical performance of EP/MeTHPA